Glucophage (Metformin) 850 - 1000 mg Merck

Ingredient: Metformin
Manufacturer: Merck
Brand Name: Glucophage
Category: Diabetes
Glucophage (Metformin) 850 - 1000 mg Merck
Item price: $0.35

Glucophage is an oral hypoglycemic drug from the biguanide group. Increases the sensitivity of peripheral receptors to insulin and stimulates the absorption of glucose by muscle cells. It inhibits gluconeogenesis in the liver.

Delays the absorption of carbohydrates in the intestines. It has a beneficial effect on lipid metabolism: it lowers total cholesterol, triglycerides and LDL. Glucophage reduces hyperglycemia, without leading to the development of hypoglycemia, does not stimulate insulin secretion and does not have a hypoglycemic effect in healthy individuals.

Special instructions

During treatment with Glucofage, it is necessary to regularly monitor the blood picture. In the case of surgery or during pregnancy, you should switch to insulin. Co-administration with alcohol, diuretics is contraindicated, iodine should not be used as radiopaque.

Overdose

Symptoms: when using Glucophage in a dose of 85 g, hypoglycemia was not observed, however, the development of lactic acidosis was noted. The early symptoms of lactic acidosis are nausea, vomiting, diarrhea, fever, abdominal pain, muscle pain, in the future it is possible to increase breathing, dizziness, impaired consciousness, development of coma

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Treatment: immediate abolition of Glucofage, urgent hospitalization, determination of the concentration of lactate in the blood; if necessary, carry out symptomatic therapy. To remove lactate and metformin from the body, hemodialysis is most effective.

How to take, course of administration and dosage

For patients not receiving insulin, 500 mg 3 times a day or 1 g 2 times a day during or after meals are prescribed in the first 3 days. From the 4th day to the 14th day - 1 g 3 times a day. After the 15th day, the dose of Glucofage is adjusted based on blood sugar and the presence of glucose in the urine. The maintenance dose is from 100 mg to 200 mg per day. Glucophage in the form of retard tablets is usually used for maintenance therapy.

Special instructions

Side effects from the digestive system can be reduced by prescribing antacids, atropine derivatives or antispasmodics. To avoid the development of these side effects, it is recommended to prescribe Glucophage during or at the end of a meal 2-3 times / day. With constant dyspepsia, glucophage should be discontinued.
During the period of use of the drug, it is recommended to monitor liver and kidney function.

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Glucophage should be discontinued 48 hours before and during the period of 48 hours after the X-ray examination using radiopaque agents.
Against the background of the use of the drug Glucofage, alcohol and ethanol-containing drugs should not be consumed.

Do not use when

impaired liver and kidney function
planned operation
hypersensitivity to the drug Glucofage.

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Glucofage indications for use

Type 2 diabetes mellitus (non-insulin dependent) in adults with diet therapy ineffectiveness (especially with concomitant obesity);
In combination with insulin in type 2 diabetes mellitus (non-insulin-dependent), especially with severe obesity with secondary insulin resistance.