Cempes (Cefdinir) 300-600 mg Sanovel

Ingredient: Cefdinir
Manufacturer: Sanovel
Brand Name: Omnicef
Category: Antibiotics
Cempes 300-600 mg

Pharmacodynamic properties

cefdinir is a semi-synthetic third-generation antibiotic of cephalosporins. The mechanism of action is determined by inhibition of cell wall synthesis.

It has a bactericidal effect on a wide range of aerobic and anaerobic microorganisms, gram (+) and gram (-) and retains its high stability in the presence of beta-lactamases, penicillin-resistant microorganisms as a result of some cephalosporins susceptible to Cefdinir.
Cefdinir is effective in the treatment of infections caused by Staphylococcus aureus, Enteroccocus fecalis. Cefdinir inhibit neutrophils from myeloperoxidase secreted during stimulation of their neurotransmitters.

Cefdinir is effective in the treatment of infections caused by Staphylococcus aureus (including strains producing beta-lactamases, with the exception of strains resistant to methicillin), Enterococcus fecal, pneumococcus (only strains sensitive to penicillin), Streptococcus pyrrolidonyl peptidicyl metaphylazine-sensitive (staphylococcus epidermal) streptococci group B, Streptococcus viridans, hemophilic (including strains producing beta-lactamases), Haemophilus ragat Ciepgai (including strains producing beta-lactamases), moraxell cataris (including sta we are producing beta-lactamase), Citrobacter Diversus Escherichia coli, Klebsiella pneumonia, Proteus Mirabilis.

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Pharmacokinetic properties

absorption Maximum plasma concentrations determined 24 hours after oral administration. The concentration in the blood plasma does not depend on the administered dose. To 300 mg, Cefdinir bioavailability is 21%, and 16% at a dose of 600 mg. Cefdinir is rapidly absorbed, the rate of absorption is not dependent on the diet.
In order for 300 mg of Cefdinir indices to be determined: Cmax (mg / ml) = 1.60 after 2.9 hours and 600 mg Cmax (mg / ml) = 2.87 after 3 hours.

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Cefdinir does not accumulate in plasma once or twice a day in patients with normal renal function.
Distribution Distribution volume is 0.67 in children l / kg (± 0.29).
Plasma protein conjugate up to 60-70% in adults and children. Conjugation is not dose dependent.
Metabolism: Only a small amount of cefdinir is metabolized.
Excretion: Cefdinir is excreted unchanged mainly through the kidneys.
Following oral administration of a dose of Ceftinex® in patients with normal renal function, the half-life is 1.7 hours.

Renal clearance is 2.0 (± 1.0) ml / min / kg after administration of 300 mg and 600 mg in patients with normal liver function. In the body without changes in the urine, respectively - 18.4% (± 6.4) and 11.6% (± 4.6).

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Clearace cefdinir is reduced in patients with impaired renal function, therefore, in these patients, or patients undergoing hemodialysis, dose adjustments.