Ingredient: Amlodipine Besylate, Valsartan
Manufacturer: Novartis
Brand Name: Exforge
Category: Blood Pressure
Item price: Exforge 5/160 mg $0.64
Item price: Exforge 10/160 mg $0.75
Composition and release form Exforge
Film-coated tablets:
1 tablet contains amlodipine besilate 6.94 and 13.87 mg, valsartan 80 and 160 mg,
excipients: microcrystalline cellulose, crospovidone, magnesium stearate, colloidal silicon dioxide, hypromellose (hydroxypropyl methylcellulose), titanium dioxide (E171), yellow iron oxide (E172), macrogol 4000 (polyethylene glycol 4000), talc;
in a package of 14 or 28 pcs.
Pharmacological action Exforge
Exforge is a combined antihypertensive drug containing active substances with a complementary mechanism for controlling blood pressure. Amlodipine, a derivative of dihydropyridine, belongs to the class of slow calcium channel blockers (BMCC), valsartan belongs to the class of angiotensin II receptor antagonists.
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The combination of these components has a mutually complementary antihypertensive effect, which leads to a more pronounced decrease in blood pressure compared with that of monotherapy with each drug.
Indications Exforge
Arterial hypertension (for patients who are shown combination therapy).
Contraindications Exforge
Hypersensitivity to the components of the drug; pregnancy.
The safety of Exforge use in patients with unilateral or bilateral renal artery stenosis or stenosis of a single kidney artery, in patients after recent kidney transplantation, as well as children and adolescents under 18 years of age, has not been established.
Dosage and administration Exforge
Exforge should be taken orally, washed down with a small amount of water, 1 time per day. regardless of the meal time.
The recommended daily dose of Exforge is 1 tablet in a dose of 5/80 mg or 5/160 mg or 10/160 mg.
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When prescribing to elderly patients, patients with initial or moderate impaired renal function (CC> 30 ml / min), with impaired liver function or with liver diseases, with cholestasis, changes in the dosage regimen are not required.
Side effects Exforge
From the respiratory system: often - nasopharyngitis, flu; sometimes - cough, pain in the throat and larynx.
From the sensory organs: rarely - visual impairment, tinnitus; sometimes - dizziness associated with impaired function of the vestibular apparatus.
From the side of the central nervous system and peripheral nervous system: often - headache; sometimes - dizziness, drowsiness, orthostatic dizziness, paresthesia; rarely - anxiety.
From the cardiovascular system: sometimes - tachycardia, palpitations, orthostatic hypotension; rarely - syncopal state, marked decrease in blood pressure.
From the digestive system: sometimes - diarrhea, nausea, abdominal pain, constipation, dry mouth.
Dermatological reactions: sometimes - skin rash, erythema; rarely - hyperhidrosis, exanthema, itching.
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From the musculoskeletal system: sometimes - swelling of the joints, back pain, arthralgia; rarely - muscle cramps, a feeling of heaviness throughout the body.
From the urinary system: rarely - pollakiuria, polyuria.
From the reproductive system: rarely - erectile dysfunction.
Other: often - pastiness, swelling of the face, peripheral edema, fatigue, flushing, asthenia, a feeling of heat.
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