Ingredient: Valsartan
Manufacturer: Novartis
Brand Name: Diovan
Category: Blood Pressure
Item price: Diovan 80 mg $1.00
Item price: Diovan 160 mg $1.29
Item price: Diovan 320 mg $2.54
Special instructions
During treatment with Diovan in patients with essential arterial hypertension, regular monitoring of laboratory parameters is not required.
Deficiency in the body of sodium and / or a decrease in bcc. In patients with a pronounced deficiency in the body of sodium and / or BCC, for example, receiving high doses of diuretics, in rare cases, at the beginning of treatment with Diovan, hypotension may occur, accompanied by clinical manifestations. Before starting treatment with Diovan, a correction of the sodium and / or bcc content in the body should be carried out, including by reducing the dose of the diuretic.
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In the case of hypotension, the patient should be laid down, legs raised. If necessary, intravenously infuse 0.9% sodium chloride solution. After blood pressure stabilizes, treatment can continue.
Renal artery stenosis. The use of Diovan in a short course in 12 patients with renovascular hypertension, which developed a second time due to unilateral renal artery stenosis, did not lead to any significant changes in renal hemodynamics, serum creatinine concentration or blood urea nitrogen. However, given that other drugs that affect RAAS can cause an increase in serum urea and creatinine concentrations in patients with bilateral or unilateral renal artery stenosis, monitoring of these indicators is recommended as a precaution.
Impaired renal function. Patients with impaired renal function do not require dose adjustment. However, for severe disorders (when Cl creatinine is less than 10 ml / min), caution is advised.
Impaired liver function. In patients with liver failure, dose adjustment is not required, with the exception of cases of cholestasis. Valsartan is excreted mainly unchanged with bile, and it has been shown that in patients with bile duct obstruction Cl valsartan is reduced. When prescribing valsartan to these patients, special care should be taken.
CHF / period after myocardial infarction. In patients with heart failure or after a myocardial infarction, starting treatment with Diovan, a slight decrease in blood pressure is often noted, and therefore it is recommended to control blood pressure at the beginning of therapy. Subject to the recommendations on the dosage regimen, there is usually no need to discontinue Diovan because of hypotension.
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Due to inhibition of RAAS in sensitive patients, changes in kidney function are possible. In patients with severe heart failure, treatment with ACE inhibitors and angiotensin receptor antagonists may be accompanied by oliguria and / or an increase in azotemia and (rarely) acute renal failure and / or death. Therefore, an assessment of renal function in patients with heart failure and patients after acute myocardial infarction is necessary.
Combination therapy In patients with heart failure, caution should be exercised when using a combination of an ACE inhibitor, beta-blocker, and valsartan.
In case of arterial hypertension, Diovan can be prescribed both as monotherapy and in conjunction with other antihypertensive drugs, in particular, with diuretics.
In CHF, Diovan can be prescribed both as monotherapy and in conjunction with other drugs - diuretics, digitalis drugs, as well as ACE inhibitors or beta-blockers.
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It is possible to use Diovan in combination with other medications prescribed after myocardial infarction, namely thrombolytics, acetylsalicylic acid, beta-blockers and statins.
Influence on the ability to drive a car and work with mechanisms. Patients taking Diovan should be careful when driving and operating machinery.
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