Ingredient: Hydrochlorothiazide, Valsartan
Manufacturer: Novartis
Brand Name: Diovan HCT
Category: Blood Pressure
Co-Diovan 80 mg / 12.5 mg
Co-Diovan 160 mg / 12,5 mg
Co-Diovan 160 mg / 25 mg
Co-Diovan 320 mg / 25 mg
Co-Diovan 320 mg / 12.5 mg
Item price: $0.64 - $1.50
Undesirable effects such as abdominal pain, visual impairment, anxiety, arthralgia, arthritis, bronchitis, dyspepsia, shortness of breath, impotence, insomnia, muscle cramps of the lower extremities, rapid urination, palpitations, rashes, sprains, and urinary infections were observed with a frequency of less than 1% ways, viral infections, edema, asthenia, vertigo. The causal relationship of these phenomena with the use of Co-Diovan has not been established.
Post-marketing studies indicate very rare cases of angioedema, rash, pruritus, and other hypersensitivity / allergic reactions, including serum sickness and vasculitis. In some cases, impaired renal function was observed.
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On the part of laboratory indicators: in 2.2% of patients receiving Co-Diovan, serum potassium concentrations decreased by more than 20% (the decrease in this indicator in the group of patients receiving placebo was 3.3%). In controlled clinical trials, 1.4% of patients receiving Co-Diovan showed an increase in serum creatinine concentration (compared with 1.1% for a group of patients receiving placebo).
Hydrochlorothiazide is widely used for many years, and more often in doses exceeding that which is part of Co-Diovan. The following adverse reactions have been reported during monotherapy with thiazide diuretics, including hydrochlorothiazide. Often - urticaria and other types of rash, loss of appetite, nausea and vomiting, postural hypotension (the severity of which increases with alcohol, the use of drugs for anesthesia or sedatives), impotence.
Special instructions
Deficiency in the body of sodium and / or circulating blood volume (BCC): In patients with a pronounced deficiency in the body of sodium and / or BCC, for example, receiving high doses of diuretics, in rare cases arterial hypotension with clinical manifestations may occur at the beginning of Co-Diovan treatment. Before starting treatment with Co-Diovan, a correction of the sodium content in the body and / or BCC should be carried out. In the case of the development of hypotension, the patient should be laid and, if necessary, carry out iv infusion of saline. After stabilization of blood pressure, treatment with Co-Diovan can be continued.
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Renal artery stenosis: With caution, the drug should be used in patients with unilateral or bilateral renal artery stenosis or stenosis of a single kidney artery. The safety of Co-Diovan in patients with unilateral or bilateral renal artery stenosis or artery stenosis of a single kidney has not been established.
Application for impaired liver function: No change in the dose of Co-Diovan is required in patients with mild to moderate impaired liver function in the absence of cholestasis, although the drug should be used with caution in this category of patients. Liver diseases do not significantly affect the pharmacokinetics of hydrochlorothiazide, therefore, dose reduction is not required. There are currently no data on the use of valsartan in patients with severely impaired liver function.
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Application for impaired renal function: Patients with impaired renal function with creatinine clearance (CC) of more than 30 ml / min do not require dose adjustment. Currently, there is no data on the use of Co-Diovan in patients with severe renal impairment (CC less than 30 ml / min) and in patients.
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